Linda B. Piller, MD

How one large academic trial adopted a coordinating center model-helping drive early-model RBM gains

The largest antihypertensive trial ever conducted throughout North America, ALLHAT, was organized using a coordinating center model for oversight. Regional coordinators played a key role in carrying this trial out.

Analysis of the largest antihypertensive trial ever offers useful blueprint for sites in boosting subject enrollment.

Data on the relationship between investigator characteristics and cardiovascular clinical trial patient recruitment are extremely limited in scientific literature. An analysis of ALLHAT, the largest antihypertensive clinical study ever conducted, identifies key investigator and site characteristics that can strengthen subject enrollment.