Tools4Patient Predicts Placebo Response in Osteoarthritis Trials
Tools4Patient recently presented data showing its Placebell predicted placebo response in a Phase II randomized controlled trial (RCT) for osteoarthritis (OA). Placebell is technology using predictive modeling that is proven to reduce the impact of the placebo response in clinical trials under real-world conditions. Data from the Phase II RCT, “Predicting the Placebo Response in OA to Improve the Precision of the Treatment Effect Estimation,” was presented as a late-breaking abstract at the OARSI Connect Virtual World Congress on Osteoarthritis.
The placebo response is a major contributing factor to late-stage clinical trial failures in many therapeutic areas, and Placebell’s predictive method addresses this complex challenge. Placebell combines machine learning-based algorithms with individual patient psychology and personality data to predict the individual placebo response in a patient before the first dose of a drug is administered.
In the study, Tools4Patient applied a Placebell chronic pain model that had been built by meta-analysis that included individual data from 211 placebo-treated patients from several studies conducted by Tools4Patient. The model was pre-specified and used to predict placebo response in all trial patients receiving an intra-articular injection of a novel compound in the sponsored Phase II RCT. Results were compared for five different endpoints in the trial: average pain score, three components of the WOMAC battery focusing on pain, joint stiffness and physical function, and the patient global assessment score.
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Behind the Buzz: Why Clinical Research Leaders Flock to SCOPE Summit
February 7th 2025In this episode, we meet with Micah Lieberman, Executive Conference Director for SCOPE Summit (Summit for Clinical Ops Executives) at Cambridge Innovation Institute. We will dive deep into the critical role of collaboration within the clinical research ecosystem. How do we bring together diverse stakeholders—sponsors, CROs, clinical trial tech innovators, suppliers, patients, sites, advocacy organizations, investors, and non-profits—to share best practices in trial design, program planning, innovation, and clinical operations? We’ll explore why it’s vital for thought leaders to step beyond their own organizations and learn from others, exchanging ideas that drive advancements in clinical research. Additionally, we’ll discuss the pivotal role of scientific conferences like SCOPE Summit in fostering these essential connections and collaborations, helping shape the future of clinical trials. Join us as we uncover how collective wisdom and cross-industry partnerships are transforming the landscape of clinical research.
Phase III Trial Data Show Subcutaneous Pembrolizumab as Noninferior to IV Keytruda
March 31st 2025Subcutaneous administration of pembrolizumab with chemotherapy demonstrated a nearly 50% reduction in patient chair and treatment room time while maintaining efficacy and safety endpoints compared to intravenous Keytruda.
Reaching Diverse Patient Populations With Personalized Treatment Methods
January 20th 2025Daejin Abidoye, head of solid tumors, oncology development, AbbVie, discusses a number of topics around diversity in clinical research including industry’s greatest challenges in reaching diverse patient populations, personalized treatment methods, recruitment strategies, and more.
