ACRIN Conducts PET Trials in Effort to Contribute to More Accurate Research
July 14, 2009-Philadelphia, PA
American College of Radiology (ACR) Image Metrix works closely with the American College of Radiology Imaging Network (ACRIN) to conduct Positron Emission Tomography (PET) trials. The PET core laboratory of ACRIN qualifies sites to participate in multicenter research trials by reviewing the quantitative data of PET scans and qualitatively reviewing clinical PET images from each site.
In a recent paper published by the Journal of Nuclear Medicine (July 12, 2009) , of 101 detailed scanner applications, 12% failed because of incorrect standardized uptake value (SUV) or normalization calibrations. Minimizing errors in SUV measurement is critical to achieving accurate quantification in clinical trials. ACRIN’s PET core laboratory shows that many sites are unable to maintain accurate SUV calibrations without additional training or supervision.
“The emerging role of PET imaging endpoints as in vivo biomarkers requires imaging studies to produce reliable quantitative, semi-quantitative and qualitative results that can be used to assess disease status. Ensuring such consistency in multi-center clinical trials that involve imaging is problematic. The problem stems from the fact that the data acquisition and reconstruction are performed in many different settings and often with different types of instrumentation. As described in our most recent peer reviewed publication, ACRIN has managed to develop a robust system to streamline data collection, data management and processing. Such system is paving the way for a better integration of molecular imaging in drug discovery processes,” stated Deputy Co-chair and Medical Director, PET Core Laboratory, ACRIN, Barry A. Siegel, MD.
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